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Related Concept Videos

Flow Sheet01:17

Flow Sheet

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Flowsheets are valuable tools in nursing documentation. They enable healthcare professionals to efficiently record and monitor various patient assessments and measurements in a consolidated format.
Here's a closer look at the examples of flowsheets commonly used by nurses:
Graphic Sheet Documentation:
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Exocrine Glands: Unicellular and Multicellular Glands01:29

Exocrine Glands: Unicellular and Multicellular Glands

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Exocrine glands are classified as unicellular and multicellular. The unicellular glands are scattered single cells, such as goblet cells, found in the mucous membranes of the small and large intestines. On the other hand, multicellular exocrine glands develop as secretory sheets, like the internal lining of the abdomen or chest. Such secretory sheets release their secretions directly into the lumen of these organs. In addition, some multicellular glands have deep-seated secretory units to...
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The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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The Mammary Glands01:12

The Mammary Glands

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The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
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The Pituitary Gland01:17

The Pituitary Gland

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The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
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Related Experiment Video

Updated: Jan 22, 2026

Cannulation of the Mouse Submandibular Salivary Gland via the Wharton's Duct
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Cannulation of the Mouse Submandibular Salivary Gland via the Wharton's Duct

Published on: May 14, 2011

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Using cell sheets to regenerate mouse submandibular glands.

Kihoon Nam1, Kyungsook Kim2, Spencer M Dean1

  • 11School of Dentistry, The University of Utah, Salt Lake City, UT USA.

NPJ Regenerative Medicine
|July 10, 2019
PubMed
Summary
This summary is machine-generated.

Thermoresponsive cell sheets show promise for salivary gland regeneration. Double-layered sheets significantly improve tissue formation, cell differentiation, and saliva secretion, offering a new therapy for hyposalivation.

Keywords:
Preclinical researchRegenerative medicine

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Related Experiment Videos

Last Updated: Jan 22, 2026

Cannulation of the Mouse Submandibular Salivary Gland via the Wharton's Duct
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Cannulation of the Mouse Submandibular Salivary Gland via the Wharton's Duct

Published on: May 14, 2011

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Retroductal Nanoparticle Injection to the Murine Submandibular Gland

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Temperature-responsive polymer grafted dishes enable cell sheet harvesting.
  • Cell sheets preserve cell-cell junctions, extracellular matrices, and tissue-like behaviors.
  • Previous studies demonstrated efficacy in various tissue regeneration applications.

Purpose of the Study:

  • To evaluate thermoresponsive cell sheets for salivary gland regeneration.
  • To compare single-layer versus multi-layer cell sheet delivery for optimal outcomes.
  • To assess cell differentiation and tissue integrity for treating hyposalivation.

Main Methods:

  • Culturing cells on thermoresponsive polymer-coated dishes.
  • Harvesting and layering cell sheets (single vs. double).
  • In vitro characterization of cell sheet structure and function.
  • In vivo assessment of tissue formation, differentiation, and saliva secretion.

Main Results:

  • Single cell sheets formed polarized structures with maintained cell junctions and secretory granules in vitro.
  • Layering two cell sheets created a glandular-like pattern in vitro.
  • Double-layer cell sheets significantly enhanced in vivo tissue formation, cell differentiation, and saliva secretion compared to single layers.
  • Single cell sheets showed modest improvements, while double layers demonstrated robust growth.

Conclusions:

  • Thermoresponsive cell sheets are viable for salivary gland regeneration.
  • Double-layer cell sheets provide superior results for tissue formation, cell differentiation, and recovered tissue integrity.
  • This approach offers a promising therapeutic strategy for hyposalivation treatment.