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Role of Macrophages in Pregnancy and Related Complications

Manoj K Jena1,2, Neha Nayak3, Kang Chen3

  • 1Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA. drmanoj.jena@gmail.com.

Archivum Immunologiae Et Therapiae Experimentalis
|July 10, 2019
PubMed

Insights

Macrophages (MФs), crucial immune cells in pregnancy, can influence outcomes. Their dysfunction is linked to disorders, suggesting MФs as therapeutic targets for improved pregnancy health.

Area of Science:

  • Immunology
  • Reproductive Biology
  • Cell Biology

Background:

  • Macrophages (MФs) are vital leukocytes derived from monocytes, present in most human tissues.
  • They exhibit diverse functions including phagocytosis, immune response modulation (M1/M2), and tissue-specific activities.
  • MФ dysfunction is implicated in various pregnancy complications.

Purpose of the Study:

  • To review the multifaceted role of MФs during pregnancy.
  • To explore the involvement of MФs in pregnancy disorders.
  • To highlight decidual MФs as potential therapeutic targets for pregnancy complications.

Main Methods:

  • Literature review focusing on MФs in pregnancy and related disorders.
  • Analysis of MФ phenotypes and polarities in different pregnancy stages.
  • Examination of MФ involvement in trophoblast invasion and vascular remodeling.

Main Results:

  • MФs are the second-largest leukocyte population in the decidua, crucial for early pregnancy processes.
  • Altered MФ polarity (M1-M2) is associated with pregnancy disorders like preeclampsia and infertility.
  • MФs also influence tumor growth and immune rejection, indicating their immunomodulatory capacity.

Conclusions:

  • Decidual MФs play a critical role in normal pregnancy and are implicated in its complications.
  • Targeting MФ polarity offers a promising therapeutic strategy for treating pregnancy disorders.
  • Further research into MФs could lead to novel treatments for adverse pregnancy outcomes.
Keywords:
DecidualizationHuman pregnancyMacrophagePolarityPreeclampsiaVEGF

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