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Perspectives on Neuroscience
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The pathogenesis of mucositis: updated perspectives and emerging targets

J Bowen1, N Al-Dasooqi2, P Bossi3

  • 1Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia. joanne.bowen@adelaide.edu.au.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|July 10, 2019
PubMed

Insights

Researchers reviewed recent mucositis literature, identifying key mediators of toxicity and therapeutic targets. Technological advances show promise for revolutionizing mucositis research and treatment.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pharmacology

Background:

  • Mucositis research and treatment is a rapidly evolving field.
  • The MASCC/ISOO Mucositis Study Group regularly assesses literature on pathogenesis, mechanisms, and therapies.
  • Previous reviews have provided perspectives and recommendations.

Purpose of the Study:

  • To assess progress in mucositis research since the last review.
  • To identify new targets for further investigation.
  • To summarize perspectives and recommendations on novel therapeutic approaches.

Main Methods:

  • A systematic literature review of 164 articles published between January 2011 and June 2016.
  • Assessment of established and emerging mediators of toxicity.
  • Evaluation of technological advances in mucositis research.

Main Results:

  • Research momentum in mucositis pathogenesis is accelerating.
  • New models and interventions targeting specific injury mechanisms are being utilized.
  • Technological advances offer potential to revolutionize mucositis research.

Conclusions:

  • Significant progress has been made in understanding mucositis pathogenesis.
  • Focused effort is needed to translate rationally targeted interventions to clinical practice.
  • Novel therapeutic approaches are emerging, driven by technological advancements.
Keywords:
MicrobiomeMucositisPathogenesisPermeabilityPerspectivesTechnology

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