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Persistent and transgenerational effects of risperidone in zebrafish.

Fabiana Kalichak1,2, Heloisa Helena de Alcantara Barcellos1,3, Renan Idalencio1,3

  • 1Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.

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Antipsychotic drug risperidone exposure in zebrafish larvae causes lasting anti-predator behavior deficits in adults and offspring. This highlights environmental risks of pharmaceutical residues on aquatic wildlife survival.

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Area of Science:

  • Environmental toxicology
  • Aquatic ecotoxicology
  • Behavioral toxicology

Background:

  • Behavior is key for animal survival and environmental interaction.
  • Pharmaceutical residues, like risperidone, in water can alter fish behavior.
  • Long-term and transgenerational effects of such exposures are poorly understood.

Purpose of the Study:

  • To investigate the persistent and transgenerational effects of risperidone exposure on zebrafish behavior.
  • To assess the impact of environmentally relevant concentrations of risperidone on non-target aquatic organisms.

Main Methods:

  • Zebrafish were exposed to risperidone during embryonic and larval stages.
  • Anti-predatory behavior was assessed in adulthood.
  • Behavioral changes in the subsequent generation were evaluated.

Main Results:

  • Zebrafish exposed to risperidone showed impaired anti-predatory behavior in adulthood, indicating a persistent effect.
  • Some behavioral alterations were observed in the offspring of exposed zebrafish, suggesting a transgenerational effect.
  • Even short exposures during development led to lifelong and inherited behavioral changes.

Conclusions:

  • Environmental risperidone residues pose long-term risks to aquatic life.
  • Altered behaviors can endanger species reliant on behavioral responses for survival.
  • Developmental exposure to pharmaceuticals can have profound, lasting impacts on fish populations.