Related Experiment Video

Updated: Jan 22, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

18.2K

Association between vertebral bone mineral density, myocardial perfusion, and long-term cardiovascular outcomes: A

Michael Fiechter1,2,3, Susan Bengs4,5, Andrea Roggo4

  • 1Department of Nuclear Medicine, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland. Michael.Fiechter@usz.ch.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|July 10, 2019
PubMed

Insights

Low bone mineral density (BMD) predicts major adverse cardiac events (MACEs) in coronary artery disease (CAD) patients, particularly in men. This sex-dependent association suggests BMD assessment may aid cardiovascular risk stratification.

Area of Science:

  • Cardiology
  • Radiology
  • Gerontology

Background:

  • Coronary artery disease (CAD) presents differently in men and women, necessitating refined cardiovascular risk assessment.
  • Bone mineral density (BMD) alterations are linked to heart conditions and may be sex-modified.
  • The relationship between BMD, myocardial perfusion, and cardiac outcomes, considering sex, remains unclear.

Purpose of the Study:

  • To investigate the sex-specific association between BMD and cardiovascular outcomes in patients undergoing CAD evaluation.
  • To determine if BMD predicts major adverse cardiac events (MACEs) in a diverse patient cohort.
  • To explore the link between BMD and myocardial perfusion or left ventricular ejection fraction.

Main Methods:

  • 491 patients (mean age 65.9 years, 32.4% women) underwent 13N-ammonia PET/CT for CAD assessment.
  • Patients were monitored for MACEs over a median follow-up of 4.3 years.
  • Statistical analyses included log-rank tests and proportional hazards regression, with a focus on sex-BMD interactions.

Main Results:

  • Lower BMD (≤100 HU) was associated with significantly reduced event-free survival (P=.037).
  • Reduced BMD independently predicted MACE (P=.015), with a significant sex-BMD interaction (P=.007).
  • Lower BMD correlated with abnormal myocardial perfusion and impaired ejection fraction in men, but not in women.

Conclusions:

  • The association between low BMD and cardiovascular disease is sex-dependent.
  • BMD quantification during myocardial perfusion imaging may enhance cardiovascular risk assessment, especially in men.
  • These findings highlight the importance of considering sex in the interpretation of BMD in cardiac patients.
Abstract

Keywords:
CADMPIPETdiagnostic and prognostic applicationmolecular imaging

More Related Videos

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction14:19

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

12.0K
Myocardial Infarction and Functional Outcome Assessment in Pigs12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.6K

Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.1K
Density, Specific Weight, Specific Gravity and Compressibility of Fluid01:27

Density, Specific Weight, Specific Gravity and Compressibility of Fluid

Density, specific weight, specific gravity, and compressibility are fundamental properties of fluids. Density is the mass per unit volume, characterizing the mass of a fluid system. It influences buoyancy, pressure, flow dynamics, viscosity, thermal conductivity, and sound propagation. For instance, in pipeline design, accurate density measurements ensure that the pipeline can handle the fluid's mass.
Specific weight represents the weight per unit volume and is calculated by multiplying...
1.5K
Water and Mineral Acquisition02:34

Water and Mineral Acquisition

Specialized tissues in plant roots have evolved to capture water, minerals, and some ions from the soil. Roots exhibit a variety of branching patterns that facilitate this process. The outermost root cells have specialized structures called root hairs that increase the root surface, thus increasing soil contact. Water can passively cross into roots, as the concentration of water in the soil is higher than that of the root tissue. Minerals, in contrast, are actively transported into root cells.
35.4K
Minerals01:26

Minerals

Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
 
Major...
1.1K
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
108.5K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.3K