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Impaired Smooth Pursuit During Transient Global Amnesia
Sung Hee Kim1, Young Ho Park2, SangYun Kim2
1Department of Neurology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Korea.
Journal of Clinical Neurology (Seoul, Korea)
|July 10, 2019
Summary
Smooth pursuit (SP) eye movements are impaired during transient global amnesia (TGA). This suggests that visual motion processing deficits, particularly in the right hemisphere, may contribute to spatial disorientation in TGA patients.
Area of Science:
- Neuroscience
- Ophthalmology
- Cognitive Neurology
Background:
- Transient global amnesia (TGA) involves episodic memory impairment.
- The hippocampus-parietooccipital network, crucial for memory, also influences smooth pursuit (SP) eye movements.
Purpose of the Study:
- To investigate SP function in patients experiencing TGA.
- To explore the link between oculomotor and memory systems in TGA.
Main Methods:
- Evaluated horizontal SP in 145 TGA patients within 1 day of the event.
- Assessed SP gains at peak target velocities of 10°/s and 20°/s.
- Compared TGA patient SP gains to age-matched controls.
Main Results:
- TGA patients exhibited significantly lower SP gains in both directions and at both velocities compared to controls.
- SP asymmetry was observed in TGA patients, with lower gains during rightward pursuit.
- This asymmetry occurred irrespective of lesion laterality.
Conclusions:
- Cortical visual motion processing is affected during or shortly after TGA.
- Right hemisphere visual motion processing appears more impacted.
- Impaired dynamic visual information processing may underlie TGA-related spatial disorientation.
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