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Updated: Jan 22, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Total Synthesis of the Antimalarial Ascidian Natural Product Albopunctatone
Glenn A Pullella, Adam P Wdowiak, Melissa L Sykes1
1Discovery Biology, Griffith Institute for Drug Discovery , Griffith University , Nathan , Queensland , Australia.
Abstract:
The first approaches to the 10'-anthronyl-2-anthraquinone skeleton have been devised, allowing two syntheses of the marine natural product albopunctatone. Both routes involve regioselective addition of a nucleophilic masked anthraquinone to a protected chrysazin derivative; the best affords albopunctatone in five steps and 35% overall yield. Albopunctatone exhibits potent inhibitory activity against Plasmodium falciparum and negligible toxicity to a range of other microbial pathogens and mammalian cells.
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