Creating the Next Generation of Translational Geroscientists

Area of Science:

• Gerontology and Geriatric Medicine
• Translational Research
• Clinical Trial Design

Background:

• Advances in aging research offer promising geroscience therapeutics for age-related diseases.
• A significant challenge is the limited number of investigators skilled in early-stage geroscience clinical trials.
• Existing training pathways are inadequate to meet the growing need for such expertise.

Purpose of the Study:

• To address the bottleneck in early-stage geroscience clinical trials by developing a strategy for training investigators.
• To establish consensus on the necessary competencies, candidate identification, credentialing, and program implementation for translational geroscience training.
• To foster a multidisciplinary research environment for developing transformative aging therapeutics.

Main Methods:

• Convened experts (basic scientists, gerontologists, clinicians) at the National Institute on Aging R24 Geroscience Network retreat.
• Discussed identification, recruitment, and training of investigators for early-phase geroscience trials.
• Developed a consensus on training program structure, content, and implementation.

Main Results:

• Identified essential subject domains and competencies for geroscience trial investigators.
• Proposed strategies for identifying and credentialing suitable trainees.
• Emphasized the role of foundations and funding agencies in supporting training programs.
• Highlighted the need for a diverse cadre of investigators beyond geriatricians.

Conclusions:

• Translational geroscience training programs are crucial for developing investigators capable of conducting early-stage trials.
• Such programs can cultivate a supportive culture for multidisciplinary aging research.
• This initiative aims to accelerate the translation of innovative geroscience concepts into effective therapeutics for older adults, enhancing health and independence.