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High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

Transcriptome analysis revealed bisphenol A and nonylphenol affect reproduction.

Tomoaki Tanaka¹, Yuriko Ono¹, Naoki Hikihara¹

¹Laboratory of Cell Engineering, Department of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.

Reproductive Toxicology (Elmsford, N.Y.)

|July 10, 2019

Summary

Endocrine disrupting chemicals like Bisphenol A (BPA) and Nonylphenol (NP) interfere with embryonic stem cell differentiation, impacting germ cell development and reproduction. These chemicals alter key gene expressions vital for reproductive processes.

Keywords:

BPA Biological process Gene set enrichment analysis Microarray NP Stra8

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Area of Science:

Reproductive biology
Toxicology
Developmental biology

Background:

Endocrine disrupting chemicals (EDCs) effects on reproduction require comprehensive explanation.
Bisphenol A (BPA) and Nonylphenol (NP) are common EDCs with suspected reproductive impacts.

Purpose of the Study:

To validate the effects of BPA and NP on embryonic stem (ES) cell differentiation.
To investigate the functional significance of EDC exposure on germ cell development and reproduction.

Main Methods:

Utilized Gene Ontology (GO)-based microarray analysis.
Compared gene expression profiles with in vivo primordial germ cell (PGC) development data.
Performed cluster analysis of gene expression profiles.

Main Results:

BPA and NP modified the expression of germ cell-specific genes in ES cells.
EDC treatment and PGC development shared gene expression clusters related to "germ cell development" and "reproduction".
Meiosis-related genes showed increased expression upon EDC exposure within the "reproduction" GO term.

Conclusions:

BPA and NP impact germ cell-specific gene expression.
These EDCs functionally interfere with germ cell development and the biological processes of reproduction.
The study highlights the reproductive risks associated with BPA and NP exposure.