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Persuasion is the process of changing our attitude toward something based on some kind of communication. Much of the persuasion we experience comes from outside forces. How do people convince others to change their attitudes, beliefs, and behaviors? What communications do you receive that attempt to persuade you to change your attitudes, beliefs, and behaviors?
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Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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[Active surveillance of adverse event within 7 days of single versus simultaneous administration of diphtheria, tetanus, and acellular pertussis combined vaccine in children aged 2-month and 6-year-old].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2026
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Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test
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[Expert consensus on rabies exposure prophylaxis].

W W Yin1, C L Wang2, Q L Chen1

  • 1Infectious Disease Management Department, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]
|July 10, 2019
PubMed
Summary
This summary is machine-generated.

Rabies is a deadly zoonotic disease with a near 100% fatality rate. Standardized post-exposure prophylaxis (PEP) effectively prevents rabies in nearly all cases, offering crucial protection against this severe infection.

Keywords:
ImmunoglobulinLyssavirusPost-exposure prophylaxisRabiesVaccine

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Area of Science:

  • Virology: Focuses on lyssavirus, the causative agent of rabies.
  • Epidemiology: Examines rabies incidence, particularly in Asia and Africa.
  • Public Health: Addresses zoonotic disease prevention and control strategies.

Background:

  • Rabies is a fatal zoonotic disease caused by lyssavirus, affecting the central nervous system.
  • Globally, approximately 59,000 deaths occur annually, with high prevalence in Asia and Africa.
  • China faces significant rabies epidemics, with Grade II and III exposures being common.

Purpose of the Study:

  • To establish expert consensus on post-exposure prophylaxis (PEP) for rabies.
  • To provide updated guidelines for rabies prevention in China.
  • To align with international standards and recent research advancements.

Main Methods:

  • Review of the World Health Organization's 2018 position paper on rabies vaccines.
  • Consideration of recent research progress in rabies prevention.
  • Consensus reached by the Human Rabies Vaccine Technical Working Group, National Immunization Advisory Committee, and invited experts.

Main Results:

  • Standardized post-exposure prophylaxis (PEP) demonstrates nearly 100% efficacy in preventing rabies.
  • Guidelines were developed based on international recommendations and current scientific understanding.
  • Expert consensus provides a unified approach to rabies PEP in China.

Conclusions:

  • Standardized PEP is a highly effective measure for rabies prevention.
  • The expert consensus aims to improve rabies control in epidemic regions like China.
  • Updated guidelines ensure evidence-based rabies management and public health protection.