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Updated: Jan 22, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
[Childhood obesity and early target organ damage]
1Department of Epidemiology, School of Public Health, Shandong University/ Children Cardiovascular Research Center of Shandong University, Ji'nan 250012, China.
Insights
Childhood obesity can cause early damage to organs like the heart, kidneys, and liver. Early detection and interventions, including exercise and diet, are crucial for preventing long-term health issues in children.
Area of Science:
- Pediatrics
- Public Health
- Cardiology
Background:
- Childhood obesity is a significant global public health concern.
- Obesity in children can lead to early damage in vital organs.
Purpose of the Study:
- To systematically review methods for identifying early target organ damage in obese children.
- To examine the impact of obesity on specific organs (heart, vessels, kidneys, liver).
- To explore the effects of interventions like exercise and diet.
Main Methods:
- Systematic review of literature from PubMed, CNKI, and Wanfang databases.
- Analysis of studies on early target organ damage markers.
- Evaluation of intervention effects on organ damage.
Main Results:
- Obesity is linked to left ventricular hypertrophy, diastolic dysfunction, increased carotid intima-media thickness, arterial stiffness, impaired glomerular filtration rate, and non-alcoholic fatty liver disease.
- Hemodynamic changes, metabolic abnormalities, and inflammatory factors are potential mechanisms.
- Exercise and dietary interventions show promise in mitigating organ damage.
Conclusions:
- Effective strategies are needed to prevent and manage childhood obesity.
- Early identification and management of target organ damage are essential.
- Interventions targeting obesity can reduce the prevalence of associated organ damage.
Abstract:
Childhood obesity has been an important public health issue worldwide. We searched PubMed, CNKI, and Wanfang databases to perform a systematic review of how to identify early target organ (including heart, vessel, kidney and liver etc) damage in children, the effects of obesity on early target organ damage (including left ventricular hypertrophy, left ventricular diastolic dysfunction, increased carotid intima-media thickness, increased arterial stiffness, impaired glomerular filtration rate, and non-alcoholic fatty liver disease, etc), the possible biological mechanisms (including hemodynamic changes, abnormal metabolic indices, and effects of cytokines and inflammatory factors, etc), and the effects of exercise training and dietary interventions on target organ damage in obese children. Thus, it is important to take effective measures to prevent and control childhood obesity, and finally to reduce the prevalence of target organ damage.
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