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Association of NOTCH3 Gene Polymorphisms with Ischemic Stroke and its Subtypes: A Meta-Analysis

Loo Keat Wei1, Lyn R Griffiths2, Looi Irene3

  • 1Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Bandar Barat, Kampar 31900, Perak, Malaysia. wynnelkw@gmail.com.

Medicina (Kaunas, Lithuania)
|July 11, 2019
PubMed

Insights

This meta-analysis found no significant association between NOTCH3 gene polymorphisms (rs1043994, rs1044009, rs3815188) and the risk of ischemic stroke or its subtypes, including atherothrombotic and lacunar strokes.

Area of Science:

  • Genetics and Neurology
  • Molecular Biology
  • Epidemiology

Background:

  • NOTCH3 gene variations are implicated in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
  • The specific role of NOTCH3 gene polymorphisms in ischemic stroke risk and its subtypes remains incompletely understood.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between NOTCH3 polymorphisms (rs1043994, rs1044009, rs3815188) and the risk of ischemic stroke and its major subtypes.

Main Methods:

  • Systematic screening and meta-analysis of ten relevant studies using Review Manager (Revman) version 5.3.
  • Association strength measured by odds ratios and 95% confidence intervals under various genetic models.
  • Analysis focused on overall ischemic stroke, atherothrombotic stroke, and lacunar stroke risks.

Main Results:

  • Meta-analysis included data from 2077-2819 cases and 2147-3053 controls for overall ischemic stroke risk.
  • Analysis of specific subtypes involved up to 874 cases for lacunar stroke and 1013 cases for atherothrombotic stroke.
  • No statistically significant association was found between the studied NOTCH3 polymorphisms and the risk of ischemic stroke or its atherothrombotic and lacunar subtypes.

Conclusions:

  • The investigated NOTCH3 gene polymorphisms (rs1043994, rs1044009, rs3815188) do not demonstrate a significant link to the risk of developing ischemic stroke or its major subtypes.
  • These findings suggest that these specific NOTCH3 polymorphisms are not major genetic risk factors for ischemic stroke in the populations studied.

Keywords:
NOTCH3atherothrombotic strokeischemic strokelacunar strokemeta-analysissingle nucleotide polymorphisms (SNPs)

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