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Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells
Published on: June 11, 2019
The role of biomaterials in stem cell-based regenerative medicine
Xiangnan Zhao1,2, Kaige Cui1, Zongjin Li1,2,3,4
1School of Medicine, Nankai University, Tianjin 300071, PR China.
Abstract:
Stem cell therapy is a promising alternative approach to the treatment of a number of incurable degenerative diseases. However, low cell retention and survival after transplantation limit the therapeutic efficacy of stem cells for clinical translational applications. The utilization of biomaterials has been progressively successful in controlling the fate of transplanted cells by imitating the cellular microenvironment for optimal tissue repair and regeneration. This review mainly focuses on the engineered microenvironments with synthetic biomaterials in modification of stem cell behaviors. Moreover, the possible advancements in translational therapy by using biomaterials with stem cells are prospected and the challenges of the current restriction in clinical applications are highlighted.
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