Relationship between circulating microparticles and hypertension and other cardiac disease biomarkers in the elderly
Hanife Usta Atmaca1, Feray Akbas2, Hale Aral3
1Istanbul Training and Research Hospital Internal Medicine Department, Health Sciences University, Samatya, Istanbul, Turkey. hanifeusta@yahoo.com.
Background:
Microparticles are procoagulant membrane vesicles that play role in endothelium dysfunction pathogenesis and are increased in hypertension, acute/chronic vascular pathological events. Here; we aimed to compare MPs levels of hypertensive geriatric patients with healthy age-match-patients, discuss its availability as a cardiovascular biomarker and investigate its relationship with other inflammatory markers.
Methods:
Forty seven hypertensive geriatric patients (M/F;15/32) and 47 healthy controls (M/F;19/28) were included in the study. MPs levels were examined functionally through thrombin generation test (TGT) parameters (MPS Lag time, MPS ETP, MPs Peak, MPS start Tail) and compared with CRP, N/L ratio, ALT, GGT, thrombocyte parameters. Decrease in MPS Lag time, increase in MPS ETS and MPs Peak elevation were accepted as tendency to coagulation which meant an increase in number and function of MPs.
Results:
No significant difference was found between 2 groups for MPS tests (MPS Lag time, MPS ETP, MPs Peak, MPS start Tail). Platelet count was significantly higher in hypertensive patient group. There was a negative correlation between age and MPs Peak, MPS Lag time. There was a positive correlation between CRP and MPS ETP, MPs Peak values.
Conclusions:
Our present findings might help to understand the hemostasis via TGT parameters, in the elderly. Contribution of MPs to thrombosis tendency seen with aging and increased number of circulating MPs caused by hypertensive endothelial dysfunction must be taken into consideration. MPs might be accepted as vascular inflammation and damage markers and used as follow up tools of medical treatment of vascular inflammation-related diseases.
Insights
Microparticle (MP) levels did not differ significantly between hypertensive elderly patients and controls. However, MPs may serve as vascular inflammation markers, correlating with C-reactive protein (CRP) and influencing thrombosis risk.
Area of Science:
- Cardiovascular Research
- Hemostasis and Thrombosis
- Geriatric Medicine
Background:
- Microparticles (MPs) are procoagulant vesicles implicated in endothelial dysfunction and vascular diseases.
- Elevated MP levels are observed in hypertension and acute/chronic vascular pathological events.
- Understanding MP dynamics is crucial in geriatric cardiovascular health.
Purpose of the Study:
- To compare microparticle (MP) levels in hypertensive geriatric patients versus healthy controls.
- To evaluate MPs as potential cardiovascular biomarkers.
- To investigate the relationship between MPs and inflammatory markers.
Main Methods:
- Study included 47 hypertensive geriatric patients and 47 age-matched healthy controls.
- Microparticle (MP) levels assessed via thrombin generation test (TGT) parameters.
- MP levels compared with C-reactive protein (CRP), N/L ratio, ALT, GGT, and platelet counts.
Main Results:
- No significant differences in TGT-derived MP parameters between hypertensive and control groups.
- Hypertensive patients exhibited significantly higher platelet counts.
- Negative correlation between age and MP Peak/Lag time; positive correlation between CRP and MP ETP/Peak.
Conclusions:
- Findings aid understanding of hemostasis in the elderly using TGT parameters.
- MPs' contribution to age-related thrombosis and hypertensive endothelial dysfunction warrants consideration.
- MPs show potential as vascular inflammation/damage markers for monitoring treatment in related diseases.
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