Traditional use and scientific investigations of the medicinal plant Simaba cedron Planch

Simaba cedron Planch (Simaroubaceae) has frequently been reported as a traditional remedy against snake bites, malaria, gastrointestinal and other disorders. Starting in the 18^th century, European physicians and researchers made several efforts to verify the reported virtues and to isolate active principles. Most important achievements are reviewed her. From modern investigations, an anti-malarial activity seems plausible due to the quassinoids contained. An effect against snake-bites seems questionable, research about the usefulness against gastrointestinal disorders, which is also reported, is missing. Other Simaroubaceae, however, are under current investigation now.