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Peripolar cells in the avian kidney
I Morild1, J A Christensen, E Mikeler
1Gade Institute, Department of Pathology, University of Bergen, Norway.
Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1988
Summary
Furosemide significantly increased kidney peripolar cells in chickens, while DOCA did not. Granulated podocytes were observed in the DOCA group, suggesting potential lysosomal activity in peripolar cells.
Area of Science:
- Nephrology
- Animal Physiology
- Pharmacology
Background:
- Peripolar cells in avian kidneys are poorly understood.
- Diuretics like furosemide and DOCA can impact kidney function and morphology.
Purpose of the Study:
- To investigate the effect of furosemide and DOCA on peripolar cell numbers in chicken kidneys.
- To compare the kidney morphology of treated and untreated chickens.
Main Methods:
- White leghorn chickens were treated with furosemide or DOCA.
- Kidneys were fixed and sectioned for microscopic analysis.
- Peripolar cell counts were compared between groups.
Main Results:
- Furosemide treatment led to a significant increase in peripolar cells.
- DOCA treatment did not significantly alter peripolar cell numbers.
- DOCA-treated chickens exhibited granulated podocytes, with granules similar to those in peripolar cells.
Conclusions:
- Furosemide induces hyperplasia of peripolar cells in chicken kidneys.
- DOCA may affect podocyte granulation, with potential implications for peripolar cell granule composition.
- The granules in peripolar cells and podocytes may be lysosomal in nature.