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High delta-like ligand 4 expression correlates with a poor clinical outcome in gastric cancer

Youjin Kim1,2, Sun-Ju Byeon3,4, Joonyoung Hur1

  • 1Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Journal of Cancer
|July 11, 2019
PubMed

Insights

High delta-like ligand 4 (DLL4) expression in gastric cancer patients is linked to poorer survival rates. This finding suggests DLL4 could be a potential therapeutic target for anti-angiogenesis drugs in cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Delta-like ligand 4 (DLL4) and the Notch pathway are emerging targets for anti-angiogenesis cancer therapies.
  • The specific role of DLL4 in gastric cancer (GC) prognosis remains largely undefined.

Purpose of the Study:

  • To investigate the impact of DLL4 overexpression on recurrence and survival in gastric cancer (GC) patients.
  • To determine if DLL4 expression levels correlate with clinicopathological parameters and patient outcomes.

Main Methods:

  • Immunohistochemistry was used to assess DLL4 expression in 336 GC patient tissue samples.
  • Patients were categorized into high and low DLL4 expression groups based on a 50% positive staining threshold.
  • Statistical analyses correlated DLL4 expression with disease-free survival (DFS) and overall survival (OS).

Main Results:

  • High DLL4 expression was found in 19.9% of GC patients.
  • Patients with high DLL4 expression, particularly those in stages II-IV, exhibited significantly poorer DFS and OS after curative surgery.
  • The negative impact of high DLL4 expression on survival was more pronounced in advanced stages (IIIb/IV).

Conclusions:

  • Elevated DLL4 expression is a significant indicator of poor prognosis in gastric cancer patients.
  • DLL4's association with adverse survival outcomes highlights its potential as a therapeutic target for novel anti-angiogenesis treatments in GC.
  • Further research into DLL4-targeted therapies is warranted for gastric cancer management.
Keywords:
DLL4Gastric canceranti-angiogenesis

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