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Author Spotlight: Integrating 2D-HPLC-MS and Molecular Networking in Natural Medicine Analysis
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Molecular Network-Based Identification of Circular RNA-Associated ceRNA Network in Papillary Thyroid Cancer

Qin Liu1, Liang-Zhi Pan2, Min Hu2

  • 1Department of Breast Surgery, Thyroid Surgery, Huangshi Central Hospital of Edong Healthcare Group, Hubei Polytechnic University, No.141, Tianjin Road, Huangshi, Hubei, China.

Pathology Oncology Research : POR
|July 11, 2019
PubMed

Insights

Circular RNAs (circRNAs) show altered expression in papillary thyroid cancer (PTC). This study reveals key circRNA-miRNA-mRNA interactions and potential biomarkers involved in PTC development and progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Circular RNAs (circRNAs) are increasingly recognized for their roles in various cancers.
  • Their specific functions and regulatory mechanisms in papillary thyroid cancer (PTC) are not well understood.

Purpose of the Study:

  • To elucidate the regulatory mechanisms of circRNAs in papillary thyroid cancer (PTC).
  • To identify potential diagnostic and therapeutic biomarkers for PTC.

Main Methods:

  • Downloaded circRNA, mRNA, and miRNA expression data from GEO and TCGA databases.
  • Constructed circRNA-miRNA-mRNA networks using Cytoscape and STRING database.
  • Identified hub genes using MCODE and performed Gene Ontology (GO) and KEGG pathway analysis.

Main Results:

  • Identified 14 differentially expressed circRNAs (DEcircRNAs), 3106 DEmRNAs, and 142 DEmiRNAs in PTC.
  • Established a ceRNA network involving 12 circRNAs, 33 miRNAs, and 356 mRNAs.
  • A subnetwork revealed 2 DEcircRNAs, 3 DEmiRNAs, and 4 DEmRNAs linked to PTC pathogenesis.
  • Pathway analysis indicated DEmRNAs are associated with PTC onset and progression.

Conclusions:

  • Dysregulated circRNAs, miRNAs, and mRNAs play critical roles in PTC pathogenesis.
  • Identified circRNAs and their regulatory networks may serve as potential therapeutic biomarkers for PTC.
Keywords:
Competitive endogenous RNAPapillary thyroid cancercircRNAmicroRNA

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