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Related Experiment Video

Updated: Jan 22, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
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Changes in eating behavior after deep brain stimulation for anorexia nervosa. A case study.

Matteo Manuelli1, Andrea Franzini2,3, Roberta Galentino2

  • 1Dietetics and Clinical Nutrition Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy. m.manuelli88@gmail.com.

Eating and Weight Disorders : EWD
|July 11, 2019
PubMed
Summary

Deep brain stimulation (DBS) of the bed nucleus of the stria terminalis improved nutritional status, body image, and eating behaviors in a patient with severe anorexia nervosa. Normal body weight was restored after four months of treatment.

Keywords:
Anorexia nervosaBody imageDeep brain stimulationNutritional assessmentSurgical approach

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Devices

Background:

  • Anorexia nervosa (AN) is a severe psychiatric disorder with high mortality rates.
  • Treatment-refractory AN poses significant challenges, necessitating novel therapeutic approaches.
  • Deep brain stimulation (DBS) is an emerging neuromodulation technique with potential applications in psychiatric disorders.

Observation:

  • This study details the case of a 37-year-old woman with treatment-refractory AN who underwent bilateral DBS of the bed nucleus of the stria terminalis.
  • Pre- and post-surgical evaluations assessed nutritional status, body image concerns, eating behaviors, and quality of life using validated instruments.
  • The patient received continuous bilateral stimulation of the bed nucleus of the stria terminalis.

Findings:

  • Significant improvements in eating behaviors, body image concerns, and nutritional status were observed within one month post-surgery.
  • The patient achieved and maintained normal body weight approximately four months after initiating DBS.
  • Psychometric scales indicated positive changes in anxiety and affective disorder symptoms.

Implications:

  • This comprehensive case study highlights the potential efficacy of DBS targeting the bed nucleus of the stria terminalis for severe AN.
  • The findings suggest that DBS may offer a viable neurosurgical treatment option for individuals with treatment-resistant anorexia nervosa.
  • A multi-faceted assessment approach, including nutritional, psychological, and behavioral metrics, is crucial for evaluating DBS efficacy in AN.