Related Experiment Video
Updated: Jan 22, 2026

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
Published on: December 5, 2016
Comprehensive analysis of differences of N6-methyladenosine RNA methylomes between high-fat-fed and normal mouse
Zupeng Luo1, Zhiwang Zhang1, Lina Tai1
1State Key Laboratory for Conservation & Utilization of Subtropical Agro-bioresources, College of Animal Science & Technology, Guangxi University, Nanning 530004, PR China.
Abstract:
Aim: To assess the m6A methylome in mouse fatty liver induced by a high-fat diet (HFD). Materials & methods: MeRIP-seq was performed to identify differences in the m6A methylomes between the normal liver and fatty liver induced by an HFD. Results: As compared with the control group, the upmethylated coding genes upon feeding an HFD were primarily enriched in processes associated with lipid metabolism, while genes with downmethylation were enriched in processes associated with metabolism and translation. Furthermore, many RNA-binding proteins that potentially bind to differentially methylated m6A sites were mainly annotated in processes of RNA splicing. Conclusion: These findings suggest that differential m6A methylation may act on functional genes through RNA-binding proteins to regulate the metabolism of lipids in fatty liver disease.
Related Concept Videos
RNA Editing
Variation: Normal Distribution, Range, and Standard Deviation
Normal Stress
When a rod is under axial loading, the internal forces and corresponding stress are normal to the plane of the section, so it is termed normal stress. It's important to...
Normal Distribution
Difference from Background: Limit of Detection
The LOD indicates the presence or absence...
Electric Potential and Potential Difference
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...

