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DNA interaction studies of rhenium compounds with Schiff base chelates encompassing biologically relevant moieties
Muhammed Bilaal Ismail1, Irvin Noel Booysen1, Matthew Piers Akerman1
1School of Chemistry and Physics, University of KwaZulu-Natal , Pietermaritzburg , South Africa.
Abstract:
Herein, we report the DNA interaction studies of rhenium(I) and -(V) compounds with Schiff base chelates encompassing biologically relevant moieties. More specifically, the DNA interaction capabilities of these rhenium complexes were probed using Gel Electrophoresis and Calf Thymus-DNA titrations monitored by temperature-controlled electronic spectroscopy. The DNA binding modes of the metal compounds were corroborated by molecular docking simulations. In addition, the synthesis and characterization of a novel facial tricarbonyl rhenium(I) compound, fac-[Re(chrs)(CO)3Br], (chrs = {3-{[(2-hydroxyphenyl)imino]methyl}-4H-chromen-4-one) are reported.
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