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Task-induced functional brain connectivity mediates the relationship between striatal D2/3 receptors and working
Matthew M Nour1,2,3,4,5, Tarik Dahoun2,3,6, Robert A McCutcheon1,2
1Institute of Psychiatry, Psychology and Neuroscience (IOPPN), King's College London, London, United Kingdom.
Elife
|July 11, 2019
Summary
Working memory relies on dopamine D2/3 receptors and brain network function. Higher dopamine receptor availability enhances the brain
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Dopamine Receptor Research
Background:
- Working memory performance is linked to striatal dopamine D2/3 receptors (D2/3Rs) and cortical network organization.
- Understanding the interplay between these factors is crucial for cognitive function.
Purpose of the Study:
- To investigate the relationship between working memory performance, default mode network (DMN) functional connectivity, and striatal D2/3R availability.
- To explore how D2/3R availability influences DMN connectivity and task performance.
Main Methods:
- Combined functional magnetic resonance imaging (fMRI) and D2/3R positron emission tomography (PET) in 51 healthy volunteers.
- Assessed working memory performance under varying cognitive loads.
- Analyzed task-induced changes in DMN functional connectivity and striatal D2/3R availability.
Main Results:
- Increased working memory load led to reduced DMN functional connectivity.
- Reduced DMN connectivity correlated with poorer working memory performance.
- Striatal D2/3R availability, particularly in the caudate, mediated the relationship between DMN connectivity and task performance.
Conclusions:
- Striatal D2/3R availability modulates DMN functional connectivity, impacting working memory.
- Findings offer insights into natural variations in working memory and cognitive impairments in disorders with altered dopamine signaling.
Keywords:
Parkinson's diseasedorsal attention networkfrontoparietal networkhumanneuroscienceschizophreniatask negative networkMore Related Videos
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