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lncRNA - Long Non-coding RNAs02:39

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Non-coding RNAs: key players in cardiac disease.

Fabian Philipp Kreutzer1, Jan Fiedler1, Thomas Thum1,2,3

  • 1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.

The Journal of Physiology
|July 11, 2019
PubMed
Summary

Non-coding RNAs (ncRNAs) play a crucial role in heart function and signaling. Understanding these molecules offers new diagnostic and therapeutic strategies for heart failure (HF) and chemotherapy-induced cardiac dysfunction.

Keywords:
CardiologyCircRNAGenomeHeart failureLncRNAMicroRNANon-coding RNA

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Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Genetics

Background:

  • Heart failure (HF) mechanisms are not fully understood.
  • Non-coding RNAs (ncRNAs) regulate myocardial function and signaling.
  • ncRNAs offer potential therapeutic and diagnostic targets.

Purpose of the Study:

  • To review ncRNA classes influencing cardiac biology.
  • To explore ncRNAs in chemotherapy-induced cardiac dysfunction.
  • To provide an outlook on specialized ncRNA functions.

Main Methods:

  • Literature review of ncRNA research in cardiovascular biology.
  • Analysis of ncRNA roles in cardiac function and dysfunction.
  • Examination of therapeutic targeting strategies for ncRNAs.

Main Results:

  • ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), significantly impact cardiac function.
  • ncRNAs are implicated in chemotherapy-induced cardiac dysfunction.
  • Emerging roles in chromatin remodeling, biomarker potential, and micropeptide generation were identified.

Conclusions:

  • ncRNAs are critical regulators of cardiac biology with significant diagnostic and therapeutic potential.
  • Targeting ncRNAs presents a promising avenue for treating heart failure and related conditions.
  • Further research into specialized ncRNA functions will advance cardiovascular medicine.