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Necrotizing Hemorrhagic Gastritis following Acute Myeloid Leukemia Induction with Midostaurin: An Unexpected

Shai Shimony1,2, Hilla Reiss Mintz3, Yulia Shvartser Beryozkin4

  • 1Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel, shaish1@clalit.org.il.

Acta Haematologica
|July 11, 2019
PubMed

Insights

Midostaurin, a treatment for acute myeloid leukemia (AML), may cause a rare complication. A patient developed necrotizing hemorrhagic gastritis after AML therapy, possibly linked to midostaurin.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Midostaurin is a tyrosine multikinase inhibitor used for acute myeloid leukemia (AML) with Fms-like tyrosine kinase-3 mutations.
  • Standard intensive chemotherapy followed by midostaurin is a treatment approach for this patient population.

Observation:

  • A 49-year-old AML patient experienced a rare gastrointestinal complication after treatment.
  • The patient developed necrotizing hemorrhagic gastritis with no signs of infection or malignancy.

Findings:

  • The severe complication occurred after achieving complete remission and blood count recovery.
  • Necrotizing hemorrhagic gastritis was potentially associated with midostaurin therapy.

Implications:

  • This case highlights a rare but serious potential adverse event of midostaurin treatment.
  • Further investigation into midostaurin's gastrointestinal toxicity in AML patients is warranted.
Keywords:
Acute myeloid leukemiaHemorrhagic gastritisMidostaurin

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