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High-level mupirocin resistance in methicillin-resistant staphylococci isolated from dogs and cats

Magdalena Kizerwetter-Świda1, Dorota Chrobak-Chmiel2, Magdalena Rzewuska2

  • 1Division of Microbiology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego, 802-786, Warsaw, Poland. magdalena_kizerwetter_swida@sggw.pl.

BMC Veterinary Research
|July 12, 2019
PubMed
Abstract

Insights

High-level mupirocin resistance (HLMR) was detected in methicillin-resistant staphylococci from pets in Poland. This includes the first report of HLMR in feline Staphylococcus haemolyticus, highlighting the need for monitoring antimicrobial resistance in animals.

Area of Science:

  • Veterinary Microbiology
  • Antimicrobial Resistance
  • Molecular Biology

Background:

  • Mupirocin is crucial for treating methicillin-resistant Staphylococcus aureus (MRSA) infections in humans.
  • Mupirocin resistance is increasingly observed in human and animal staphylococci, including methicillin-resistant Staphylococcus pseudintermedius (MRSP).
  • This study investigates high-level mupirocin resistance (HLMR) in methicillin-resistant staphylococci from companion animals.

Purpose of the Study:

  • To investigate the prevalence of HLMR in methicillin-resistant staphylococci isolated from diseased dogs and cats.
  • To identify the species and origin of staphylococci exhibiting HLMR.
  • To confirm the genetic basis of HLMR in the identified isolates.

Main Methods:

  • Screening of 140 methicillin-resistant staphylococci isolates using agar disk diffusion.
  • Confirmation of resistance via minimum inhibitory concentration (MIC) testing.
  • Detection of the ileS2 gene associated with mupirocin resistance using molecular methods.

Main Results:

  • Three isolates displayed HLMR: one methicillin-resistant S. aureus (dog), one MRSP (dog), and one methicillin-resistant S. haemolyticus (cat).
  • All resistant isolates showed MIC values >1024 μg/ml and carried the plasmid-located ileS2 gene.
  • This marks the first report of HLMR in feline S. haemolyticus.

Conclusions:

  • HLMR was confirmed in Staphylococcus isolates from companion animals in Poland.
  • The findings underscore the importance of monitoring mupirocin resistance in animal-derived staphylococci, particularly methicillin-resistant strains.
  • This surveillance is essential for understanding and managing antimicrobial resistance in veterinary medicine.
Keywords:
Staphylococcus aureusStaphylococcus haemolyticusStaphylococcus pseudintermediusileS2

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