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[Advances in the role of melatonin in infectious diseases: A review]

Yan Ma1, Kang Tang2, Chunmei Zhang2

  • 1The Fourth Team, College of Basic Medicine, Air Force Military Medical University, Xi'an 710032, China.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology
|July 12, 2019
PubMed

Insights

Melatonin (MLT) regulates circadian rhythms and modulates immune responses. This review highlights MLT's potential as a therapeutic agent against infectious diseases by enhancing immunity and inhibiting pathogens.

Area of Science:

  • Immunology
  • Endocrinology
  • Pharmacology

Background:

  • Melatonin (MLT), a hormone primarily from the pineal gland, regulates circadian rhythms.
  • Emerging research indicates MLT significantly influences immune system function.
  • MLT's role in infectious diseases is an area of growing interest.

Purpose of the Study:

  • To review the immunomodulatory effects and mechanisms of melatonin.
  • To explore the potential of melatonin in treating infectious diseases.

Main Methods:

  • Literature review of studies on melatonin's effects on the immune system.
  • Analysis of research investigating melatonin's role in infectious disease models.
  • Synthesis of findings on melatonin's impact on immune cells, cytokines, inflammation, and pathogen activity.

Main Results:

  • Melatonin influences immune cell counts and cytokine expression.
  • It reduces inflammation by decreasing inflammatory factors and leukocyte adhesion.
  • Melatonin exhibits anti-oxidative properties, mitigating inflammation-induced damage.
  • Directly inhibits pathogen replication and proliferation.

Conclusions:

  • Melatonin demonstrates multifaceted immune-regulatory functions.
  • Its anti-inflammatory, anti-oxidative, and direct antimicrobial properties are significant.
  • Melatonin presents a promising novel therapeutic target for clinical management of infectious diseases.

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