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Updated: Jan 22, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
mSphere of Influence: Clearing a Path for High-Resolution Visualization of Host-Pathogen Interactions In Vivo
1Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA shumin.tan@tufts.edu.
Abstract:
Shumin Tan works in the field of Mycobacterium tuberculosis-host interactions. In this mSphere of Influence article, she reflects on how the paper "Single-cell phenotyping within transparent intact tissue through whole-body clearing" by B. Yang et al. (Cell 158:945-958, 2014, https://doi.org/10.1016/j.cell.2014.07.017) impacted her ideas on approaches to visualize and understand heterogeneous host-pathogen interactions in vivo in 3-dimensional space at the single-cell level, through the tractable and broadly compatible tissue optical clearing methods developed.
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