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Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction.

Ryo Sasaki1, Yasuyuki Ohta1, Kota Sato1

  • 1Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.

Internal Medicine (Tokyo, Japan)
|July 12, 2019
PubMed
Summary
This summary is machine-generated.

A complicated neurodegenerative disorder, spastic paraplegia, presents with progressive lower limb spasticity. This case expands understanding with unique clinical and brain imaging findings.

Keywords:
extrapyramidal signfrontal cognitive dysfunctionspastic paraplegia

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Area of Science:

  • Neurology
  • Neuroimaging
  • Neurodegeneration

Background:

  • Spastic paraplegia is a complex neurodegenerative disorder characterized by progressive spasticity in the lower limbs.
  • Clinical presentations can vary, necessitating further investigation into atypical forms.

Observation:

  • The presented case exhibited spastic paralysis and hyperreflexia across all extremities.
  • Lead pipe rigidity was noted in the neck and bilateral upper extremities (more pronounced on the right).
  • Cognitive assessment revealed decreased scores on frontal tests.

Findings:

  • A DaTscan indicated reduced dopamine transporter accumulation in the right dorsal putamen.
  • 99mTc-ECD SPECT imaging showed hypoperfusion in the bilateral frontal lobes.
  • These findings correlate clinical symptoms with neuroimaging abnormalities.

Implications:

  • This case broadens the spectrum of spastic paraplegia presentations.
  • It highlights the utility of integrated clinical and advanced neuroimaging for diagnosing complex neurological disorders.
  • Further research may elucidate the specific mechanisms underlying this complicated spastic paraplegia variant.