Outcomes of left atrial appendage occlusion using the AtriClip device: a systematic review

Area of Science:

• Cardiology
• Medical Devices
• Interventional Procedures

Background:

• Atrial fibrillation significantly elevates stroke risk, with the left atrial appendage (LAA) identified as the primary source of emboli in most cases.
• Left atrial appendage occlusion (LAAO) is proposed as a safer alternative to long-term oral anticoagulation therapy for stroke prevention.

Purpose of the Study:

• To systematically review the safety and efficacy of the AtriClip device for epicardial LAA occlusion.
• To assess outcomes including occlusion rates, adverse events, and stroke incidence following AtriClip implantation.

Main Methods:

• A systematic review of 11 studies, adhering to PRISMA guidelines, was conducted using the keyword 'AtriClip'.
• Data from 922 patients were analyzed, focusing on demographics, interventions, procedural outcomes, and follow-up data.

Main Results:

• Successful LAA occlusion was achieved in 97.8% of patients (902/922).
• No device-related adverse events were reported.
• The incidence of stroke or transient ischemic attack post-procedure ranged from 0.2 to 1.5 per 100 patient-years.
• Anticoagulation was ceased in 59.7% of patients at follow-up.

Conclusions:

• The AtriClip device is a safe and effective option for LAA occlusion in patients with atrial fibrillation.
• It can be utilized effectively as an adjunct to cardiac surgery or as a standalone thoracoscopic procedure.