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Ex Situ Normothermic Machine Perfusion of Donor Livers
Published on: May 26, 2015
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Machine Perfusion and the Pancreas: Will It Increase the Donor Pool?
Karim Hamaoui1, Vassilios Papalois2
1Department of Surgery, Imperial College London, London, UK. karim.hamaoui08@imperial.ac.uk.
Current Diabetes Reports
|July 12, 2019
Summary
Machine perfusion (MP) offers a promising solution to increase donor pancreata availability for transplantation. This technology can assess and improve the viability of organs previously deemed unsuitable, potentially expanding transplant options.
Area of Science:
- Transplantation immunology
- Organ preservation technology
- Surgical innovation
Background:
- Pancreas transplantation significantly improves quality of life by eliminating the need for insulin.
- A decline in pancreas transplants over 20 years is linked to increased use of extended criteria (ECD) and donation after cardiac death (DCD) donors.
- Current donor demographics present challenges for pancreas allograft availability.
Purpose of the Study:
- To evaluate the potential of machine perfusion (MP) to expand the donor organ pool for pancreas transplantation.
- To explore how MP can overcome limitations posed by high-risk donor criteria.
Main Methods:
- Review of experimental models using hypothermic and normothermic MP for pancreas preservation.
- Analysis of emerging research on ex-vivo pancreatic MP in porcine and human studies.
- Discussion of the refinement needed in perfusion protocols and viability assessment tools.
Main Results:
- Experimental MP models for pancreas show promising results for organ preservation.
- MP offers superior preservation compared to cold storage and allows for organ resuscitation and manipulation.
- MP enables assessment of functional and metabolic organ viability, identifying suitability for transplantation.
Conclusions:
- Machine perfusion technology holds significant potential for pancreas preservation and optimization.
- MP can transform initially high-risk donor pancreata into viable organs for transplantation.
- This approach could substantially increase the availability of suitable pancreata, addressing current transplant limitations.
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