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Updated: Jan 22, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
06:15

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Phase II study of Dovitinib in recurrent glioblastoma

Mayur Sharma1, Cathy Schilero1, David M Peereboom1,2

  • 1Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Ave, S73, Cleveland, OH, 44195, USA.

Journal of Neuro-Oncology
|July 12, 2019
PubMed
Abstract

Insights

Dovitinib did not improve progression-free survival in recurrent glioblastoma (GBM) patients, regardless of prior anti-angiogenic therapy. The study found no significant efficacy in prolonging PFS for GBM patients treated with dovitinib.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Dovitinib is an oral inhibitor targeting FGFR and VEGFR.
  • It was investigated as a potential treatment for recurrent or progressive glioblastoma (GBM).

Purpose of the Study:

  • To evaluate the efficacy of dovitinib in patients with recurrent GBM.
  • To compare outcomes in anti-angiogenic-naïve patients versus those with prior anti-angiogenic therapy.

Main Methods:

  • An open-label, two-arm phase II study was conducted.
  • Arm 1: anti-angiogenic-naïve recurrent GBM patients.
  • Arm 2: recurrent GBM patients progressed on prior anti-angiogenic therapy.

Main Results:

  • Six-month progression-free survival (PFS-6) was 12% in Arm 1 and 0% in Arm 2.
  • Time to progression (TTP) was similar between arms (median 1.8 months vs. 0.7-1.8 months).
  • High rates of grade 3 and 4 toxicities were observed (67% and 15%, respectively).

Conclusions:

  • Dovitinib demonstrated no efficacy in prolonging PFS for recurrent GBM patients.
  • Efficacy was not observed irrespective of prior anti-angiogenic treatment, including bevacizumab.
Keywords:
Anti-angiogenic therapyBevacizumabDovitinibGlioblastomaRecurrent

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