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An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons
Published on: May 23, 2019
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Tau Secretion: Good and Bad for Neurons.
Camille Pernègre1,2, Antoine Duquette1,2, Nicole Leclerc1,2
1Research Centre of the University of Montreal Hospital (CRCHUM), Montréal, QC, Canada.
Frontiers in Neuroscience
|July 12, 2019
Summary
Alzheimer's disease involves tau pathology spreading via neuron secretion. Understanding tau secretion mechanisms may lead to targeted therapies preventing pathological tau spread without harming beneficial physiological tau release.
Area of Science:
- Neuroscience
- Cell Biology
- Pathology
Background:
- Alzheimer's disease (AD) is characterized by neurofibrillary tangles (NFTs) of aggregated tau protein.
- Tau pathology spreads trans-synaptically, suggesting neuronal release and uptake of tau.
- Tau is detectable in cerebrospinal fluid (CSF), even in physiological conditions, indicating neuronal secretion.
Purpose of the Study:
- To review the mechanisms and functions of tau secretion in both physiological and pathological conditions.
- To explore how understanding tau secretion can inform therapeutic strategies for Alzheimer's disease.
Main Methods:
- Literature review focusing on tau secretion mechanisms.
- Analysis of existing evidence on tau release and uptake in neurons.
- Comparison of tau secretion in physiological versus pathological states.
Main Results:
- Neuronal tau secretion occurs in both healthy and diseased states.
- Pathological tau accumulation in AD may involve enhanced secretion.
- Extracellular tau might have beneficial roles in physiological conditions.
Conclusions:
- Targeting pathological tau secretion is a potential therapeutic avenue for AD.
- Differentiating between physiological and pathological tau secretion is crucial for effective treatment.
- Further research into tau secretion mechanisms can guide the development of therapies to prevent tau propagation.
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