Related Experiment Video
Updated: Jan 22, 2026
12:00
Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats
Published on: September 29, 2016
15.2K
Human Dorsal Root Ganglia
Rainer Viktor Haberberger1,2, Christine Barry1, Nicholas Dominguez1
1Pain and Pulmonary Neurobiology Laboratory, Centre for Neuroscience, Anatomy and Histology, Flinders University, Adelaide, SA, Australia.
Frontiers in Cellular Neuroscience
|July 12, 2019
Summary
This review focuses on human dorsal root ganglia (DRG) neurons, crucial for sensory information. It highlights advances in understanding human DRG neurochemistry, particularly for pain-sensing neurons, vital for therapeutic development.
Area of Science:
- Neuroscience
- Cell Biology
- Anatomy
Background:
- Dorsal root ganglia (DRG) neurons transmit sensory information to the central nervous system.
- Research has extensively characterized animal DRG neurons but human DRG neurons remain understudied.
- Understanding human DRG is essential for translational research and developing new therapies.
Purpose of the Study:
- To review historical and recent findings on human dorsal root ganglia (DRG).
- To highlight advancements in characterizing the neurochemical properties of human DRG neurons.
- To focus on nociceptive neurons within the human DRG.
Main Methods:
- Literature review of historical and emerging research on human DRG.
- Synthesis of data on DRG size, location, and neurochemical characteristics.
- Focus on studies investigating human nociceptive neurons.
Main Results:
- Human DRG size and location data are summarized.
- Advances in understanding the neurochemical profiles of human DRG neurons are presented.
- Specific attention is given to the characterization of human nociceptive neurons.
Conclusions:
- Despite limited historical focus, human DRG research is advancing.
- Characterizing human DRG neurons, especially nociceptive types, is critical for future therapeutic strategies.
- This review consolidates current knowledge and points to future research directions.
Related Concept Videos
03:02Primary and Secondary Growth in Roots and Shoots
60.2K
Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
60.2K
01:24Peripheral Nervous System: Ganglia and Nerves
5.2K
The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
5.2K
00:57Root Mean Square
3.7K
If in an experiment, data values have a probability of being both positive and negative, neither the arithmetic mean, the geometric mean, nor the harmonic mean can be used to calculate the central tendency of the data set. In particular, if the positive and negative values are equally likely, the arithmetic mean is close to zero.
For example, consider the velocity of gas molecules in a container. The gas molecules are moving in different directions, which might impart positive and negative...
For example, consider the velocity of gas molecules in a container. The gas molecules are moving in different directions, which might impart positive and negative...
3.7K
01:20Sympathetic Pathways: Sympathetic Chain Ganglia
5.9K
The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
5.9K
01:23Drugs Acting on Autonomic Ganglia: Stimulants
2.1K
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
2.1K
01:28Drugs Acting on Autonomic Ganglia: Blockers
1.6K
Ganglionic blockers inhibit autonomic activity by blocking nicotinic receptors in the autonomic ganglia, suppressing impulse transmission. These blockers lack selectivity between sympathetic and parasympathetic ganglia and are ineffective as neuromuscular junction antagonists. They can be categorized into two groups:
1.6K