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Related Experiment Video

Updated: Jan 22, 2026

Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats
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Human Dorsal Root Ganglia.

Rainer Viktor Haberberger1,2, Christine Barry1, Nicholas Dominguez1

  • 1Pain and Pulmonary Neurobiology Laboratory, Centre for Neuroscience, Anatomy and Histology, Flinders University, Adelaide, SA, Australia.

Frontiers in Cellular Neuroscience
|July 12, 2019
PubMed
Summary

This review focuses on human dorsal root ganglia (DRG) neurons, crucial for sensory information. It highlights advances in understanding human DRG neurochemistry, particularly for pain-sensing neurons, vital for therapeutic development.

Keywords:
DRGMRIimmunohistochemistrynociceptorsatellite cells

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Anatomy

Background:

  • Dorsal root ganglia (DRG) neurons transmit sensory information to the central nervous system.
  • Research has extensively characterized animal DRG neurons but human DRG neurons remain understudied.
  • Understanding human DRG is essential for translational research and developing new therapies.

Purpose of the Study:

  • To review historical and recent findings on human dorsal root ganglia (DRG).
  • To highlight advancements in characterizing the neurochemical properties of human DRG neurons.
  • To focus on nociceptive neurons within the human DRG.

Main Methods:

  • Literature review of historical and emerging research on human DRG.
  • Synthesis of data on DRG size, location, and neurochemical characteristics.
  • Focus on studies investigating human nociceptive neurons.

Main Results:

  • Human DRG size and location data are summarized.
  • Advances in understanding the neurochemical profiles of human DRG neurons are presented.
  • Specific attention is given to the characterization of human nociceptive neurons.

Conclusions:

  • Despite limited historical focus, human DRG research is advancing.
  • Characterizing human DRG neurons, especially nociceptive types, is critical for future therapeutic strategies.
  • This review consolidates current knowledge and points to future research directions.