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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Itch, Scratching, and Sleep Mediate the Association between Disease Severity and Quality of Life in Pruritic Dermatoses: A Cross-Sectional Study.

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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
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Pruritus in Autoimmune and Inflammatory Dermatoses.

Claudia Zeidler1, Manuel Pedro Pereira1, Flavien Huet2,3

  • 1Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.

Frontiers in Immunology
|July 12, 2019
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Summary

Pruritus, or itching, is a common and severe symptom in autoimmune skin diseases that impacts patient quality of life. This review highlights the need for better recognition and effective treatments for disease-specific itch.

Keywords:
IL31atopic dermatitisbullous pemphigoiditchprurituspsoriasissubstance P

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Area of Science:

  • Dermatology
  • Immunology
  • Pathophysiology

Background:

  • Pruritus is a frequent and debilitating symptom in autoimmune and inflammatory dermatoses.
  • Its severity can correlate with disease activity or manifest independently, significantly impacting patients' quality of life.
  • Despite its prevalence, disease-specific pruritus remains under-recognized and undertreated, with limited clinical trials evaluating targeted therapies.

Purpose of the Study:

  • To review the characteristics and pathomechanisms of pruritus in various dermatoses.
  • To discuss current antipruritic treatment strategies for these conditions.
  • To emphasize the importance of recognizing and managing pruritus in autoimmune-related skin diseases.

Main Methods:

  • Literature review of studies on pruritus in autoimmune and inflammatory dermatoses.
  • Analysis of disease characteristics and pathomechanisms associated with pruritus.
  • Evaluation of existing research on antipruritic treatments.

Main Results:

  • Pruritus is a significant symptom across autoimmune bullous diseases, connective tissue diseases, and autoimmune-associated dermatoses (e.g., atopic dermatitis, psoriasis vulgaris).
  • The underlying mechanisms of pruritus in these conditions are complex and varied.
  • Current therapeutic options for disease-specific pruritus are limited and require further investigation.

Conclusions:

  • The high prevalence of pruritus in autoimmune and inflammatory dermatoses underscores its clinical significance.
  • Effective recognition and management of pruritus are crucial for improving patient outcomes.
  • There is a clear need for developing and validating efficient antipruritic therapies tailored to specific dermatological conditions.