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Distal Consequences of Oral Inflammation
Joanne E Konkel1,2, Conor O'Boyle1, Siddharth Krishnan1,2
1Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom.
Frontiers in Immunology
|July 12, 2019
Summary
Periodontitis, an oral inflammatory disease, causes tooth and bone loss and impacts systemic health. It is linked to chronic diseases like rheumatoid arthritis and Alzheimer's disease, affecting distant body sites.
Area of Science:
- Oral Health and Systemic Medicine
- Inflammatory Disease Mechanisms
Background:
- Periodontitis is a widespread chronic inflammatory condition affecting tooth-supporting structures.
- Beyond oral health, periodontitis is associated with systemic diseases and inflammation in distant body sites.
Purpose of the Study:
- To review diseases impacted by periodontitis.
- To explore mechanisms linking oral inflammation to systemic health disruption.
Main Methods:
- Review of epidemiological and experimental studies.
- Analysis of proposed mechanisms of systemic impact.
Main Results:
- Periodontitis is linked to the development or worsening of numerous chronic conditions.
- Oral inflammation may disrupt homeostasis in distant organs and tissues.
Conclusions:
- The inflammatory state of the oral cavity significantly influences overall systemic health.
- Understanding these links is crucial for managing periodontitis and associated systemic conditions.
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