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Related Experiment Video

Updated: Jan 22, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

Complement Activation in Autoimmune Bullous Dermatoses: A Comprehensive Review.

Gareth Edwards¹, Gilles F H Diercks², Marc A J Seelen³

¹Department of Dermatology, University Medical Center Groningen, Groningen, Netherlands.

Frontiers in Immunology

|July 12, 2019

Summary

The complement system (CS) plays a key role in autoimmune bullous dermatoses (AIBD) by mediating inflammation and blister formation. Targeting the CS offers promising therapeutic strategies for these conditions.

Keywords:

auto-immune bullous dermatosis bullous pemphigod complement dermatitis herpetiformis epidermolysis bullosa acquisita linear IgA bullous dermatoses mucus membrane pemphigoid pemphigus

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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

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Measuring the 50% Haemolytic Complement CH50 Activity of Serum

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Published on: March 29, 2010

Area of Science:

Immunodermatology
Complement System Biology

Background:

Autoimmune bullous dermatoses (AIBD) involve autoantibodies targeting skin components.
The complement system (CS) is activated by these autoantibodies, leading to inflammation and blistering.
Complement deposition is a diagnostic marker in AIBD.

Purpose of the Study:

To review the role of the complement system in the pathogenesis of various AIBD.
To discuss potential complement-targeted therapies for AIBD.

Main Methods:

Review of existing literature on AIBD and complement activation.
Analysis of data from animal models and human skin biopsies.
Discussion of therapeutic strategies targeting complement pathways.

Main Results:

The complement system is integral to the inflammatory processes in AIBD.
Specific complement pathways contribute to blister formation in different AIBD.
Complement deposition patterns aid in AIBD diagnosis.

Conclusions:

The complement system is a critical mediator in the pathogenesis of AIBD.
Targeting complement components and pathways represents a viable therapeutic avenue for AIBD.
Further research into complement's role can refine diagnostic and therapeutic approaches.