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Mechanochemical Friedel-Crafts acylations

Mateja Đud1, Anamarija Briš1, Iva Jušinski1

  • 1Ruđer Bošković Institute, Bijenička cesta 54, HR-10002 Zagreb, Croatia.

Beilstein Journal of Organic Chemistry
|July 12, 2019
PubMed
Summary

Solvent-free Friedel-Crafts acylation using mechanochemistry enables efficient synthesis of ketone-functionalized aromatics. This green chemistry approach optimizes reaction conditions and broadens substrate scope for industrial applications.

Keywords:
Friedel–Crafts reactionball millingmechanochemistry

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