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Related Concept Videos

Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Related Experiment Video

Updated: Jul 16, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

KIMURA'S Disease - An E[X]clusive Condition.

Prashanthi Gurram1, Saravanan Chandran1, Priyadarshini Parthasarathy1

  • 1Department of Oral and Maxillofacial Surgery, SRM Kattankulathur Dental College and Hospital, SRM University, Kancheepuram, Tamil Nadu, India.

Annals of Maxillofacial Surgery
|July 12, 2019
PubMed
Summary

Kimura's disease, a rare autoimmune disorder, requires a multidisciplinary approach for diagnosis. Key diagnostic indicators include histopathology, immunohistochemistry, and elevated eosinophils, aiding in differentiating it from other causes of lymphadenopathy.

Keywords:
Cervicofacial lymphadenopathyKimura's diseaseimmunohistochemistry

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Area of Science:

  • Immunology
  • Pathology
  • Otolaryngology

Background:

  • Kimura's disease is a rare autoimmune condition with unknown causes.
  • Diagnosis is challenging due to non-specific clinical and laboratory findings, often requiring exclusion of other diseases.
  • A systematic, multidisciplinary approach is crucial for accurate diagnosis.

Observation:

  • Presents a case of a middle-aged Asian woman with cervicofacial lymphadenopathy without other concurrent illnesses.
  • Emphasizes the importance of a comprehensive diagnostic protocol including clinical, radiological, and histopathological evaluations.
  • Highlights the diagnostic significance of specific biochemical markers, such as an elevated absolute eosinophil count.

Findings:

  • Histopathological examination and immunohistochemical analysis are essential for confirming Kimura's disease.
  • An elevated absolute eosinophil count is a key biochemical marker supporting the diagnosis.
  • The presented case underscores the diagnostic protocol for Kimura's disease.

Implications:

  • This case report reinforces the diagnostic criteria for Kimura's disease.
  • It highlights the necessity of integrating various diagnostic modalities for rare conditions.
  • Further understanding of Kimura's disease management and prognosis is discussed based on literature review.