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Mycophenolate mofetil and atopic dermatitis: systematic review and meta-analysis
Kevin Phan1,2, Saxon D Smith3,4,5
1Department of Dermatology, Liverpool Hospital, Sydney, Australia.
The Journal of Dermatological Treatment
|July 12, 2019
Summary
Mycophenolate mofetil (MMF) shows promising efficacy for severe atopic dermatitis, with most patients achieving remission. Long-term use requires monitoring for infections, particularly herpes.
Area of Science:
- Dermatology
- Pharmacology
- Immunology
Background:
- Severe atopic dermatitis often necessitates systemic or potent treatments.
- Off-label use of mycophenolate mofetil (MMF) has been reported for refractory cases or those with adverse effects to other systemic agents.
Purpose of the Study:
- To evaluate the efficacy and safety of off-label mycophenolate mofetil (MMF) in patients with atopic dermatitis.
Main Methods:
- Systematic electronic literature search across six databases up to April 2019.
- Data extraction and analysis focused on predefined clinical endpoints.
- Inclusion of 140 cases with atopic dermatitis treated with MMF.
Main Results:
- 77.6% of patients achieved partial or full remission of atopic dermatitis.
- Significant reduction in SCORAD scores (mean decrease of 18 points, p=.0002).
- Long-term treatment (≥1 year) was associated with increased risk of herpes infections.
Conclusions:
- Current evidence, though low-quality, suggests MMF is a promising treatment for adult and pediatric atopic dermatitis.
- Ongoing monitoring for infections is crucial during long-term MMF therapy.
- Further high-quality research is warranted to confirm efficacy and safety profiles.
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