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Relationship between serum homocysteine and different menopausal stage
1Department of Gynecology and Obstetrics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Summary
Serum homocysteine levels increase with menopausal status, particularly in postmenopausal women. This study highlights the association between menopause transition and elevated homocysteine, a key factor in cardiovascular health.
Area of Science:
- Endocrinology
- Cardiovascular Health
- Women's Health
Background:
- Elevated homocysteine is a risk factor for cardiovascular diseases.
- Menopause significantly alters hormonal profiles and metabolic functions in women.
- Understanding homocysteine levels during menopause is crucial for preventative health strategies.
Purpose of the Study:
- To investigate serum homocysteine levels in menopausal women.
- To explore the association between menopausal status, blood lipids, and homocysteine concentrations.
Main Methods:
- Recruited 366 women aged 40-60 not on menopausal hormone therapy.
- Collected demographic data and menopausal status via questionnaires.
- Utilized binary logistic stepwise regression to analyze hyperhomocysteinemia associations.
Main Results:
- Hyperhomocysteinemia prevalence was 43% (premenopause), 26.4% (transition), and 45% (postmenopause).
- Mean homocysteine level was 9.75 µmol/l, significantly higher in postmenopause (p=0.043).
- Menopausal transition was associated with a 2.027-fold increased odds of elevated homocysteine compared to postmenopause (p=0.005).
Conclusions:
- Serum homocysteine levels are significantly associated with menopausal status.
- Homocysteine concentrations progressively increase across menopausal stages.
- Physiological changes during menopause transition may lead to higher homocysteine levels in postmenopausal women.
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