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Updated: Jan 22, 2026

Reconstruction of Single-Cell Innate Fluorescence Signatures by Confocal Microscopy
Published on: May 27, 2020
Single-Cell Signature Explorer for comprehensive visualization of single cell signatures across scRNA-seq datasets
Frédéric Pont1,2,3,4,5,6,7, Marie Tosolini1,2,3,4,5,6,7, Jean J Fournié1,2,3,4,5,6,7
1Centre de Recherches en Cancérologie de Toulouse, INSERM UMR1037, Toulouse, France.
Abstract:
The momentum of scRNA-seq datasets prompts for simple and powerful tools exploring their meaningful signatures. Here we present Single-Cell_Signature_Explorer (https://sites.google.com/site/fredsoftwares/products/single-cell-signature-explorer), the first method for qualitative and high-throughput scoring of any gene set-based signature at the single cell level and its visualization using t-SNE or UMAP. By scanning datasets for single or combined signatures, it rapidly maps any multi-gene feature, exemplified here with signatures of cell lineages, biological hallmarks and metabolic pathways in large scRNAseq datasets of human PBMC, melanoma, lung cancer and adult testis.
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