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Selective sensing Ca2+ with a spiropyran-based fluorometric probe.

Li Wang1, Yuanjun Yao2, Jiao Wang2

  • 1Institute of Environmental Science, Shanxi University, Taiyuan, 030006, China.

Luminescence : the Journal of Biological and Chemical Luminescence
|July 12, 2019
PubMed
Summary

A novel spiropyran (SP) fluorescence probe, L, was developed for calcium ion (Ca2+) detection. This probe exhibits a selective "turn-on" fluorescence response and a visible color change, enabling sensitive Ca2+ sensing in solutions.

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Area of Science:

  • Supramolecular Chemistry
  • Analytical Chemistry
  • Materials Science

Background:

  • Spiropyrans (SP) are photochromic compounds with reversible ring-opening and ring-closing mechanisms.
  • SP derivatives serve as versatile platforms for detecting various analytes through fluorescence.
  • Developing selective and sensitive probes for metal ions is crucial for environmental and biological monitoring.

Purpose of the Study:

  • To synthesize and characterize a functionalized spiropyran (SP) fluorescence probe, designated L.
  • To investigate the probe's capability for detecting calcium ions (Ca2+) in ethanol solutions.
  • To evaluate the selectivity, sensitivity, and signaling mechanism of the SP probe for Ca2+.

Main Methods:

  • Synthesis and characterization of the functionalized spiropyran probe L.
  • Fluorescence spectroscopy to monitor the interaction between probe L and Ca2+.
  • UV-Vis spectroscopy to observe colorimetric changes upon Ca2+ binding.
  • Determination of the probe's binding stoichiometry and detection limit for Ca2+.

Main Results:

  • Probe L demonstrated a selective 'turn-on' fluorescence response upon binding with Ca2+ in ethanol.
  • A 1:1 ligand/metal complex formation was observed, leading to a new emission band at 604 nm.
  • Visible color changes (colorless to pink) and UV-induced changes (blue to red) confirmed Ca2+ detection.
  • The calculated detection limit for Ca2+ was 4.53 × 10^-8 M.

Conclusions:

  • The functionalized spiropyran probe L effectively detects Ca2+ with high sensitivity and selectivity.
  • The probe's dual signaling mechanism (fluorescence and color change) facilitates easy detection.
  • SP-based derivatives offer promising potential for developing novel sensors for metal ion detection in various systems.