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Author Spotlight: Utilizing Infraorbital Nerve Ligation in Mice for Investigating Trigeminal Neuropathic Pain and Treatment Strategies
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Trigeminal Pain Responses in Obese ob/ob Mice Are Modality-Specific.

Heather L Rossi1, Nichelle R Raj2, Blanca Marquez de Prado2

  • 1Department of Neurology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA; Department of Neurology, University of Iowa, Iowa City, IA, USA.

Neuroscience
|July 12, 2019
PubMed
Summary

Leptin-deficient (ob/ob) mice exhibit reduced trigeminal thermal pain sensitivity, unlike diet-induced obese mice. This suggests leptin plays a specific role in pain processing, independent of hyperphagia.

Keywords:
capsaicinleptinmigraineobesitythermal hypoalgesiatrigeminal nociception

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Area of Science:

  • Neuroscience
  • Pain Research
  • Obesity Studies

Background:

  • Obesity is linked to pain disorders like migraine, but the underlying mechanisms are unclear.
  • Trigeminal nociception is vital in migraine pathophysiology and is altered in diet-induced obesity.
  • It remains unknown if genetic obesity models also show altered trigeminal processing.

Purpose of the Study:

  • To investigate if leptin-deficient (ob/ob) mice exhibit trigeminal hyperalgesia.
  • To compare trigeminal nociception in genetic (ob/ob) versus diet-induced obesity models.
  • To explore the role of leptin in trigeminal pain processing.

Main Methods:

  • Evaluated trigeminal thermal nociception using an operant thermal assay in ob/ob and control mice.
  • Assessed capsaicin-evoked nociception and conditioned place aversion.
  • Measured TRPV1 expression in trigeminal ganglia and evaluated hyperphagia's contribution.

Main Results:

  • Unexpectedly, ob/ob mice displayed significant trigeminal thermal hypoalgesia, not hyperalgesia.
  • Ob/ob mice showed normal responses to capsaicin-evoked nociception and aversion, unlike diet-induced obese mice.
  • No significant differences in TRPV1 expression or hyperphagia's contribution to observed behaviors were found.

Conclusions:

  • Leptin deficiency (ob/ob) results in trigeminal thermal hypoalgesia, contrasting with diet-induced obesity.
  • Leptin's role in pain processing appears specific, influencing thermal nociception differently than capsaicin responses.
  • These findings highlight distinct mechanisms by which genetic versus diet-induced obesity impact pain pathways.