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Bombesin receptors as potential targets for anticancer drug delivery and imaging

Deep Pooja1, Anusha Gunukula1, Nitin Gupta2

  • 1Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, Telangana, India.

The International Journal of Biochemistry & Cell Biology
|July 12, 2019
PubMed

Insights

Targeting cancer cells precisely is a major challenge. Peptide ligands, like those targeting Bombesin (Bn) receptors, offer a promising solution for enhanced drug delivery and diagnostics in various human cancers.

Area of Science:

  • Oncology
  • Nanotechnology
  • Pharmacology

Background:

  • Precise delivery of anticancer agents to cancer cells remains a significant challenge in oncology.
  • Peptides are increasingly utilized as ligands for targeted drug and gene delivery systems.
  • Overexpression of Bombesin (Bn) receptors in various human cancers presents a therapeutic target.

Purpose of the Study:

  • To review the role of peptide ligands in enhancing precision cancer drug delivery.
  • To discuss the targeting of overexpressed Bombesin (Bn) receptors for cancer therapy and diagnostics.
  • To highlight the benefits of peptide-based targeting strategies in oncology.

Main Methods:

  • Review of current literature on peptide-drug conjugates and peptide-modified delivery systems.
  • Analysis of studies investigating Bombesin (Bn) receptor expression in human malignancies.
  • Exploration of therapeutic and diagnostic applications utilizing Bn receptor targeting.

Main Results:

  • Peptide ligands enhance on-site delivery of anticancer agents, improving imaging and therapeutic efficacy.
  • Peptide ligands offer advantages such as small size, cost-effectiveness, high specificity, and flexibility.
  • Bombesin (Bn) receptors are overexpressed in prostate, breast, small cell lung, and pancreatic cancers.

Conclusions:

  • Peptide-based targeting strategies, particularly those involving Bombesin (Bn) receptors, show significant promise for improving cancer treatment and diagnosis.
  • Targeting overexpressed Bn receptors can lead to increased therapeutic efficacy and reduced adverse effects of chemotherapy.
  • Further development of peptide ligands offers a versatile approach for precision oncology interventions.
Keywords:
Bombesin peptideBombesin receptorsCancerDrug deliveryGastrin releasing peptideImagingTargeting

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