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MicroRNA targeting by quercetin in cancer treatment and chemoprotection

Doo Hwan Kim1, Haroon Khan2, Hammad Ullah2

  • 1Department of Bioresources and Food Science, Konkuk University, Seoul, 05029, South Korea.

Pharmacological Research
|July 12, 2019
PubMed

Insights

Quercetin, a dietary phytochemical, shows promise in cancer therapy by modulating microRNAs (miRNAs). This review explores quercetin

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • MicroRNA (miRNA) dysregulation is implicated in cancer progression.
  • Dietary phytochemicals, like quercetin, possess anti-cancer properties including antioxidant and anti-inflammatory effects.
  • Quercetin has demonstrated the ability to modulate key cancer-related miRNAs.

Purpose of the Study:

  • To review the evidence supporting quercetin's role in miRNA-mediated cancer chemoprevention and therapy.
  • To comprehensively understand the health benefits and pharmacological potential of quercetin.
  • To present the integration of technology platforms for miRNA biomarker and drug discovery.

Main Methods:

  • Literature review of clinical and preclinical studies.
  • Analysis of experimental data on quercetin's effects on cancer-relevant miRNAs (e.g., let-7, miR-21, miR-146a, miR-155).
  • Discussion of technological advancements in miRNA biomarker and drug discovery.

Main Results:

  • Quercetin modulates multiple cancer-associated miRNAs, inhibiting cancer initiation and development.
  • Evidence supports quercetin's potential in miRNA-mediated chemopreventive and therapeutic strategies across various cancers.
  • Technological platforms are being integrated for enhanced miRNA biomarker and drug discovery.

Conclusions:

  • Quercetin is a promising agent for miRNA-mediated cancer therapy and chemoprevention.
  • Further research into quercetin's pharmacological potential and integration with advanced technologies is warranted.
  • Targeting miRNAs with dietary compounds like quercetin offers a novel therapeutic avenue in oncology.
Keywords:
Bioinformatic toolsCancerCarcinogenesisChemopreventionEpigenetic regulationFlavonoids

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