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Updated: Jan 22, 2026

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Detection of Abnormal Prion Protein by Immunohistochemistry
Published on: May 5, 2023
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Familial Os Odontoideum: Proatlas Segmentation Abnormality
Hidetoshi Sato1, Nobuyuki Shimokawa1, Hiroaki Matsumoto1
1Department of Neurosurgery, Tsukazaki Hospital, Hyogo, Japan.
World Neurosurgery
|July 12, 2019
Summary
Familial os odontoideum, a rare condition, may stem from proatlas segmentation abnormalities, not just trauma. Surgical intervention showed successful outcomes in affected sisters.
Area of Science:
- Orthopedic Surgery
- Developmental Biology
- Genetics
Background:
- Os odontoideum is an independent ossicle distinct from a hypoplastic odontoid process.
- Its pathogenesis is debated, with theories including congenital, developmental, and traumatic origins.
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