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Relationship between inflammatory markers and mild cognitive impairment in Chinese patients with type 2 diabetes: a

Miaoyan Zheng1, Baocheng Chang1, Liqiang Tian2

  • 1NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Metabolic Diseases Hospital & Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

BMC Endocrine Disorders
|July 13, 2019
PubMed
Abstract

Insights

Inflammatory markers like IL-6 and hs-CRP are linked to mild cognitive impairment (MCI) in type 2 diabetes (T2D). Serum folate levels may alter the hs-CRP association with MCI in T2D patients.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Immunology

Background:

  • Inflammatory markers are linked to mild cognitive impairment (MCI) in type 2 diabetes (T2D).
  • Serum folate levels correlate with both MCI and inflammation.
  • The interplay between inflammatory markers, serum folate, and MCI in T2D remains understudied.

Purpose of the Study:

  • To investigate the association between inflammatory markers and MCI in Chinese T2D patients.
  • To explore the potential modifying role of serum folate levels in this association.

Main Methods:

  • A case-control study involving 126 T2D patients (63 with MCI, 63 without).
  • Measurement of clinical parameters, serum folate, hs-CRP, IL-6, and TNF-α.
  • Statistical analysis using Spearman correlation and logistic regression.

Main Results:

  • T2D patients with MCI exhibited higher serum hs-CRP, IL-6, and TNF-α levels.
  • Serum folate showed a negative correlation with hs-CRP, TNF-α, and IL-6.
  • While IL-6 remained associated with MCI, the hs-CRP association diminished after adjusting for folate, particularly in higher folate subgroups.

Conclusions:

  • Serum IL-6 and hs-CRP are associated with MCI risk in Chinese T2D patients.
  • Serum folate appears to modify the relationship between hs-CRP and MCI in this population.
Keywords:
FolateHigh-sensitivity C-reactive proteinInflammationMild cognitive impairmentType 2 diabetes

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