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Related Concept Videos

Transcription Factors02:16

Transcription Factors

82.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Transcription Elongation Factors02:35

Transcription Elongation Factors

13.5K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
13.5K
Transcription Elongation Factors02:35

Transcription Elongation Factors

4.6K
4.6K
General Transcription Factors01:30

General Transcription Factors

6.8K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
6.8K
Transcription01:10

Transcription

155.7K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
155.7K
Master Transcription Regulators02:23

Master Transcription Regulators

7.7K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.7K

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Related Experiment Video

Updated: Jan 22, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

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TFutils: Data structures for transcription factor bioinformatics.

Benjamin J Stubbs1, Shweta Gopaulakrishnan1, Kimberly Glass1

  • 1Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

F1000Research
|July 16, 2019
PubMed
Summary
This summary is machine-generated.

The TFutils Bioconductor package simplifies complex transcription factor (TF) bioinformatics by integrating diverse data resources. It enhances precision for TF target and binding site analyses, aiding genomic studies.

Keywords:
BioconductorGene expressionGene regulationTranscription factors

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

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Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences
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Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences

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Related Experiment Videos

Last Updated: Jan 22, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

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Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences
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Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences

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Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • DNA transcription is a complex biological process.
  • Bioinformatic analysis of transcription factors (TFs) is challenging due to numerous data sources and annotations.
  • Integrating TF data requires robust computational tools.

Purpose of the Study:

  • To introduce the TFutils Bioconductor package for enhanced TF data analysis.
  • To provide standardized data structures and functions for TF-related bioinformatics.
  • To facilitate integrative analyses involving transcription factors.

Main Methods:

  • Developed the TFutils R/Bioconductor package.
  • Integrated TF catalogs from CISBP, HOCOMOCO, and Gene Ontology (GO).
  • Incorporated TF target data from MSigDb and ENCODE experimental results.

Main Results:

  • TFutils offers curated catalogs of human TFs from multiple sources.
  • The package provides methods for enumerating TF binding sites, including ENCODE data.
  • Demonstrated integration of TF binding patterns with genome-wide association study (GWAS) data.

Conclusions:

  • TFutils enhances the precision and utility of integrative TF analyses.
  • The package serves as a valuable resource for researchers studying transcription factor functions and regulation.
  • Facilitates cross-resource data integration for TF-centric genomic research.