Data from differentially expressed proteins in platelet components associated with adverse transfusion reactions

Area of Science:

• Proteomics
• Transfusion Medicine
• Biochemistry

Background:

• Adverse transfusion reactions (ATRs) are a significant concern in clinical practice.
• Understanding the molecular mechanisms underlying ATRs is crucial for improving transfusion safety.
• Platelet components (PCs) are frequently transfused, and their role in ATRs requires further investigation.

Purpose of the Study:

• To identify differentially expressed proteins in blood platelet components (PCs) associated with adverse transfusion reactions (ATRs).
• To provide a comprehensive proteomic dataset for further research into ATR mechanisms.
• To extend previous findings on protein expression in platelet components related to ATRs.

Main Methods:

• High-throughput proteomics analysis was performed on platelet components (PCs) from ATR patients and controls.
• A Q Exactive high-resolution tandem mass spectrometer was utilized for proteomic profiling.
• Data were deposited in the ProteomeXchange Consortium via the PRIDE repository (PXD003510, PXD008886).

Main Results:

• Differential protein expression patterns were identified in platelet components (PCs) associated with adverse transfusion reactions (ATRs).
• The dataset provides detailed proteomic information for both pooled (PPC) and apheresis (SDA-PC) platelet components.
• Specific proteins showing altered expression levels in ATR-associated PCs were characterized.

Conclusions:

• The identified differentially expressed proteins in platelet components (PCs) offer potential biomarkers for adverse transfusion reactions (ATRs).
• This proteomic dataset serves as a valuable resource for advancing the understanding of ATR pathogenesis.
• Further research can leverage these findings to develop strategies for mitigating transfusion risks.